Due to its unique and specific action at a receptor found only in nematodes, ZOLVIX can be used to achieve high levels of roundworm kill without unacceptable risk to operators, animals or the environment.
ZOLVIX is not toxic to the many organisms and systems required to maintain productive pastures and healthy waterways. No concerns have emerged regarding dung beetles, earthworms, algae, daphnia or soil microflora.
The active ingredient of ZOLVIX, monepantel, presents no risk of cancer, fertility problems or genetic mutations.
Exposure to ZOLVIX during a day of drenching is hundreds of times lower than exposures used during safety testing. It poses no unacceptable health risk to operators, and ZOLVIX is classified as a product of least degree of hazard by the Environmental Risk Management Authority (ERMANZ).
ZOLVIX has a wide safety margin and is readily accepted by sheep as young as 2 weeks of age (minimum weight 10 kg). Studies have shown no adverse events at 10 times the maximum recommended dose1.
ZOLVIX can be used confidently in breeding animals. It presents no specific risk to ewes during mating, gestation or lambing and can be used at standard recommended doses and with a normal level of care. Similarly, ZOLVIX presents no specific risk to breeding rams or the offspring of treated animals2.
New Zealand regulators have approved a 7-day meat withholding period for sheep treated with ZOLVIX. The withholding period for sheep milk or milk products intended for human consumption is 35 days.
References:
1. Safety of an amino- acetonitile derivative (AAD) monepantel, in weaned lambs following repeated oral administration
Malikides et al New Zealand Veterinary Journal Volume 57 Number 1 February 2009, pp10-16.
2. Reproductive safety of an amino- acetonitile derivative (AAD) monepantel, in rams following repeated oral administration
Malikides et al New Zealand Veterinary Journal Volume 57 Number 1 February 2009, pp16-22.
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